Frankie Stein / Lilith Van Helscream (voice)
Jackson Jekyll / Holt Hyde / Operetta / Additional Voice (voice)
Clawdeen Wolf / Cleo de Nile (voice)
Abbey Bominable / C.A. Cupid / Clair / Additional Voices (voice)
Lagoona Blue / Headmistress Bloodgood (voice)
Draculaura (voice)
Clawd Wolf (voice)
Deuce Gorgon / Gil Webber / Thad (voice)
Howleen Wolf / Toralei Stripe (voice)
Ghoulia Yelps / Manny Taur / Sheriff / Additional voices (voice)
Heath Burns / Mr. Rotter / Goon #2 (voice)
Robecca Steam / Venus McFlytrap (voice)
Chad / Kid #1 (voice)
Gargoyle (voice)
Goon #1 (voice)
Narrator (voice)
Nefera De Nile (voice) (uncredited)
Tiki People (voice) (uncredited)