Nigel 'Numbuh 1' Uno / Hoagie Pennywhistle 'Numbuh 2' Gilligan Jr / Numbuh 101 (voice)
Kuki 'Numbuh 3' Sanban (voice)
Wally 'Numbuh 4' Beatles / Mr. Fibb / Toilenator / Joaquin / Tommy Gilligan (voice)
Abigail 'Numbuh 5' Lincoln / Former Numbuh 11 - Cree Lincoln (voice)
Chad Dickson (voice)
Crazy Old Cat Lady/Gramma Stuffum (voice)
Mr. Boss / Mr. Fizz / Benedict Wigglestein (voice)
Fanny 'Numbuh 86' Fulbright / Computer (voice)
Stickybeard (voice)
Knightbrace / Mr. Wink (voice)
Father (voice)
Patton 'Numbuh 60' Drilovsky (voice)
Monty Uno (voice)
Grandfather (voice)
Count Spankulot (voice)
Rachael T. 'Numbuh 362' McKenzie (voice)
Sector Z Numbuh 0.1 - Bruce (voice)
Sonya - Number 83 / Lee - Numbuh 84 (voice)
Numbuh Zero / Lenny - Sector Z Numbuh 0.4 (voice)
Additional Voices (voice)
Additional Voices (voice)