Sherlock Holmes
Dr. John Watson
Dr. Grace Hart
Mrs. Martha Hudson
Inspector Lestrade
Millie
Queen Victoria
Prof. James Moriarty / Jacob Musgrave
Brawn
PC Smalls
Doxy
Flotsam
Haybag
Pickle
Mud Fog
The Judge
Lestrade's Wife
Sigmund Freud
Mark Twain
Albert Einstein
Charlie Chaplin
Houdini
Jonathan Nightingale
Mrs. Nightingale
Billy Zane
Butler
Waiter
Waiter
Telegraph Operator
Hudson's Guard
Newschild
Newschild
Newschild
Newschild
Titanic Ship Officer Liaison
Titanic Guest
Hangman
Weird Child Companion
Drooling Man Companion
Disorientated Man Companion
Priest
Titanic Ship Officer
Fight Fan #1
Fight Fan #2
Announcer
Young Sherlock Holmes
Young Watson
Sherlock's Mother
Nicotine Stains / Nancy
Jane
Seamus
Bridgette
Headmaster
Teacher #1
Teacher #2
Inky Hands
Tough Kid
Mycroft Holmes (uncredited)
Gustav Klinger (uncredited)
Mr. Algernon Barkworth (uncredited)
Mrs. Frobisher (uncredited)
Manager Mr. Petrucka (uncredited)
John (uncredited)
Herbert (uncredited)
Doxy's Dad (uncredited)
Newsie Man (uncredited)
Newsie Kid - Jimmy (uncredited)
Newsie Kid - Timmy (uncredited)
Instructing Solicitor (uncredited)
Courtroom Person 3 (uncredited)
Fitness Instructor (uncredited)
One Man Band (uncredited)
White Star-Line Girl (uncredited)
Telly-Phone Assistant (uncredited)
Yeoman of the Guard (uncredited)
British Soldier (uncredited)
Buckingham Palace Guest (uncredited)
Garden Party Guest (uncredited)
Nobleman (uncredited)
Upper Class Gentleman #1 (uncredited)
Victorian Gentleman (uncredited)
Docker (uncredited)
Russian Merchant (uncredited)