Dr. Heywood Floyd
Dr. Walter Curnow
Tanya Kirbuk
Dr. R. Chandra
Dr. David Bowman
HAL 9000 (voice)
Caroline Floyd
Dr. Vladimir Rudenko
Christopher Floyd
Victor Milson
Betty Fernandez
Maxim Brailovsky
Dimitri Moisevitch
Dr. Vasili Orlov
Irina Yakunina
Yuri Svetlanov
Nikolaj Ternovsky
SAL 9000 (voice)
Commercial Announcer
Jessie Bowman
Alexander Kovalev
Anchorman on TV
Nurse
Hospital Neurosurgeon
Dr. Hirsch
Commercial Announcer
Man on Park Bench (uncredited)