James Brown, Cris Collinsworth, Phil Simms and Warren Sapp return to preview the first week of the 2009-2010 season beginning with the Tennessee Titans vs. Pittsburgh Steelers Thursday September 10th. Joined by Bill Cowher for the opening episode, the cast looks over the big stories in the offseason, looks at how Twitter has made an impact in the NFL, looks over the 1st year head-coaches, and evaluates how they will fare this season. Plus the cast looks ahead to Week 1 with their Pick Six segment, and concludes the show by remembering the late Harry Kalas, and introduces the new voice of Inside the NFL, Scott Graham.

The cast in this episode talks about all the Week 1 highlights, what's happened with Jake Delhomme, how the Donovan McNabb injury will hurt the Eagles, the top 5 quarterbacks in football, the end of the Wildcat era, and the fear that nearly 50 games could be blacked out due to failure of selling out.