Rushing to attend the birth of his child, a fuel tanker driver crashes into Holby General's Acute Assessment Unit. Immediate evacuation of the hospital has begun as the tanker leaks petrol into the hospital basement. The driver's wife delivers a mixed-race son who is identifiably the result of an extra-marital affair. The driver dies unaware of his wife's infidelity, and as the baby begins to experience breathing difficulties, his mother rejects him. Connie Beauchamp and Alistair Taylor are forced to complete open heart surgery on a child as the evacuation continues, held hostage by the child's father. Paramedic Luke Warren fails to spot the deadly symptoms of a student with Lassa fever, and receptionist Bex Reynolds is lured up to Nightingale Wing pharmacy by a fake pharmaceutical representative. As the generator is switched off in the basement, the petrol explodes and the Nightingale building bursts into flames, trapping numerous staff members inside.

As firefighters struggle to contain the aftermath of the explosion, Connie is joined in theatre by Harry as they continue the transplant by torchlight. Rosie and Jim manage to get the baby to safety, but as debris falls, Rosie is impaled on a piece of metal. Bex is discovered by firemen and carried to safety. Alistair abandons the transplant and jumps from a fifth floor window. Critically injured, he talks nurse Donna Jackson through a life saving procedure on another patient before dying. From outside, Ric Griffin guides Connie to a maintenance corridor and bridge which will lead those trapped to a point where firefighters are waiting for them. Suddenly, the fake pharmaceutical representative rushes across behind them, damaging the bridge further and falling to his death. Jim and Rosie are left hanging from the broken bridge holding on to one of Harry's arms each. Knowing Harry will be unable to hold both their weight for much longer, Jim saves Rosie's life by letting go.

Alistair's world comes crashing down around him.

Dr Mickey Webb, a new doctor, is pranked by Charlie Fairhead and Jay Faldren using the ED starter pack.

Dr Sam Nicholls' past in Afghanistan.

Jeff and Dixie's relationship.

It's Christmas Eve and the nurses from Holby ED head out to party. Fletch dreads all the stress that the big day brings, so he busies himself sorting out everybody else's problems.

Three of the four new student nurses interview each other about their new job at the ED.

Paramedic Jeff arrives at the scene of a school coach crash.

The exclusive episode begins with Iain agreeing to visit a fellow former soldier, who he served with in Afghanistan. Persuading Sam to accompany him to the hospital where Kenny is being treated, they are surprised to discover it’s not a veterans’ hospital, but a rehabilitation centre for soldiers suffering from Post-Traumatic Stress Disorder. Inside the centre, Kenny welcomes Sam and assumes she and Iain are now together. He reminds her of all the letters Iain used to write to her, much to Sam’s confusion as she never received any. As Iain struggles to confront his own past the bond between him and Sam deepens. And when Sam has to make a call to Tom, will she tell the truth about where she is and who she is with?

On the night before their wedding, Zoe and Max head out to celebrate their final night of freedom… but will Greta’s unexpected appearance reawaken Zoe’s doubts? Meanwhile, Max and Lofty’s night takes a surprising turn when they end up back in the ED… but will Max’s mishap prevent him from getting to the registry office on time?

Cal gets more than he bargained for when Taylor presents him with a surprise. How will he react? Will Taylor stick around to find out? English

Relive the stunts, explosions, emotional storylines and Hollywood guest stars as Derek Thompson and Cathy Shipton (Charlie and Duffy) celebrate their 30 years in Casualty.

It's Christmas in the ED, and the team face an emergency blood shortage. Whilst Stevie fights to save a family man’s life, Iain takes a big risk to secure the hospital’s supply.