Lois is the perfect wife, but she's just discovered that her husband, Paul, is having yet another affair. At the urging of her neighbor, Lois hires a hitman to kill Paul, but the plan goes amok when Lois finds that Paul named his mistress as the beneficiary of his insurance policy.

Dr. Elaine Daniels learns that her ex-husband/coworker, Dr. Arthur Daniels (guest star Alex Rocco) has been dating a much younger woman. To make him jealous, Elaine flaunts a younger man under Arthur's nose. Meanwhile, the Daniels' coworkers make a bet on who will have sex first: the Daniels or the lab rats.

Guest-star Glenda Jackson portrays Dr. Doris Kruber, a talk radio psychiatrist who's taken hostage by Sally Trickleson, a Brooklyn woman who accuses Kruber's book of ruining her life.