Azumanga Daioh (2002)

Ten year old child prodigy, Chiyo Mihama, is finding it tough fitting in at high school with the girls five years her elder: Osaka (dimwitted with a weird take on the world), Tomo (a powder keg that goes off at a moment’s notice), Kagura (the competitive athlete of the bunch), Yomi (the hothead), and Sakaki (timid and obsessed with a love of animals that isn’t reciprocated). Together with their teacher, they navigate the rough waters and fun times of high school.