At Vanderbilt University Medical Center, heart transplant patient Krystal goes into cardiac arrest while waiting to be listed for a donor heart. Carlos, a young father in desperate need of a new kidney, finds a life-saving friend in live donor Adam.

Dying of heart failure and COVID-19, Reverend Kenyatta Braxton prays for a heart and double lung transplant. Recovered addict Jeff hopes a new liver can save him so he can help raise his granddaughter.

Rob has been living on supplemental oxygen and urgently needs a double lung transplant. After no fewer than 17 heart surgeries over the years, Joe has defied the odds, but now he must have a heart and liver transplant in order to survive.