Keena saves the life of a young Cree brave and, in the Indian tradition, becomes his blood brother. Not long afterward Keena is taken gravely ill, and he learns the wisdom of this old tradition.

An innocent joke starts a chain of events that may lead to war between the Cheyenne and the Blackfeet if Brave Eagle can't put a stop to it.

A stubborn young white girl who is staying at Brave Eagle's village refuses to leave with her uncle, a cavalry officer. The uncle believes she is being held against her will and determines to "rescue" her. In order to avert a war, Brave Eagle must resolve the situation.

Chief Brave Eagle is challenged by a warrior who wants to take his position as chief--in a fight to the death.

Keena, Brave Eagle's adopted son, has defied his father and joined the tribe in an attack on renegade Indians who have attacked a white settlement, and has been captured by the renegades. Brave Eagle sets out to rescue him.