Ms. Stoner unwittingly receives a mysterious strain of medical marijuana. The cosmic kush causes her to hotbox herself and her five house cats. Thus begins the cat-astrophe.

The stakes are higher as Ms. Stoner's ailments worsen and the cats' sentience fades. Fefe tries to get her paws on more Skunky Smoke while Baxter discovers a mysterious world and Dave meets a new friend.

In a crisis, Ms. Stoner hits the road to locate her missing cat, Dave, and gets unexpected help from the rest of her feline family. Meanwhile, Dave, trapped in the mysterious lab on the edge of town, is pulled into a "joint operation" by his old friend Hash Panda.