The premiere episode introduces medical residents training at the Vanderbilt Medical Center.

Train finds cancer during a routine appendectomy; Whitney and Tyson confront death while working as members on the code team; Louis reaches a breaking point after a fight with roommates.

Train races to save an elderly patient; Jeremy remembers being a rookie after a routine lumbar puncture goes awry; Erin tries to juggle her career with a relationship; Louis opens up to Whitney.

Train's girlfriend visits from New Jersey; Mike distracts Louis while working in the A-pod of the ER; Tyson doesn't believe Erin is taking her rotation seriously.

Tyson and Erin must live with patient deaths; Jeremy considers applying for Chief Resident; Mike fights through a routine procedure gone wrong.

Train makes a critical career decision; Tyson considers a life outside of medicine; Louis discovers an overlooked injury; Whitney questions whether or not she still wants to be a doctor.