The video starts with Spears going into a New York nightclub. Madonna, who is in a room filled with men smoking cigars, observes her from television monitors throughout the club. This is followed with Spears performing a dance routine inside a blacklight paint graffiti room, and the two women dancing around a metal bedframe. Spears then begins chasing Madonna in a wooden-like maze, and the latter enters a room covered with fallen leaves and stands in a swing. Once Spears finds the room, Madonna is nowhere to be found.

Spears appears with blonde hair dressed as a flight attendant, lifting the in-flight intercom as if on a phone call. After serving some of the passengers, she "accidentally" spills a drink into the lap of a seated male passenger; later beckoning a middle-aged, overweight, bespectacled male passenger to the bathroom where she seduces him. Spears then appears, completely re-dressed, and takes a ride on the back of a Ducati 999. Spears then enters Toxic Industries and gains access to a vault from which she steals a vial of green poison. The action narrative is repeatedly intercut with scenes of Spears, on all fours on the floor, wearing only diamonds.

It features Spears as a pop star fighting with a male companion as she is hounded by paparazzi. She starts to drown in her bathtub after bleeding from a head wound. In the hospital, doctors fail to resuscitate her, while simultaneously a child is born in the next room.