"Dottie the Body" lost her confidence when a large bump started growing between her thighs; Dr. Lee brings in a new, young doctor to help Tim with his big, bumpy nose; Karime is insecure about her birthmark that looks like a black eye.

Katrina has oozing, smelly boils that have taken over her life. Kim's head-to-toe tumors interfere with her sleep apnea mask, resulting in constant exhaustion. Dr. Lee and a medical student trainee help Emil and his wife, who are afraid the bump and lesion on his back might be cancerous.

Tierra is a musician with massive bumps on her ears that hold her back from performing. Dr. Zoe assists Dr. Lee helping Ryan, whose numerous head bumps undermine his life journey. Ann keeps a great attitude even as she lives with everyday pain caused by her genetic skin condition.

Dr. Lyndsey assists Dr. Lee with Lance's notoriously big bump that halted his rap dreams. Shelby has lost control of her sweet tooth, her health, and the mystery bumps she has developed. Dr. Lee proposes a long-shot cure for Jante, who has been losing pigment in her skin as well as her confidence.

Anthony is trying to move on from his troubled past, but his huge thigh lump is holding him back. Mary has a mysterious 70-year-old bump that amazes Drs. Lee and Tomassian. Sultana has a shocking red rash on her face that affects her social media success.

Dr. Lyndsey joins Dr. Lee to help David, who is fearful that the lump on his jaw might be cancer. Carla has a large, mysterious bulge on her thigh that concerns Dr. Lee. James has over 70 skin tags that he wants removed so he can get his beach body back.

Bill's swinging arm growth prevents him from living his retirement dreams. Regina distracts from the many moles on her face with a vibrant style. Budding med student Gili helps Dr. Lee solve the mystery of Cowboy Carter's extensive rash.

Dr. Lee asks Dr. Zoe to help double-team needle-shy Mary Ann's crusty skin. Isaiah's mom is concerned he is ignoring the large, growing lump over his lower spine. Maressa worries about the dangers of treating the oozing skin covering her ankles and body.

Jason has become a recluse because of a giant growth on the back of his neck.

Bryan has a genetic condition that may be causing the huge mystery bumps on his head.

Dave is a firefighter and avid cyclist whose bump gets in the way of wearing various helmets. Bree empowers others on social media by accepting her own psoriasis, but it has recently become too painful to endure.

Dee has the voice of an angel, but her huge neck hump has stolen her passion to sing. Young Eli wants to be a chef, but feels ashamed of his cheek bump and worries removing it could paralyze his face.

Stephanie has dreams of being a caterer, but is humiliated by her giant baseball-sized scalp bump. Deb is afraid that the growth on the side of her knee may eventually paralyze her.

Jimmy is a Charleston firefighter whose myriad of torso bumps make it painful to play with his young son.