Brad and Barry Klinge bring their team and their mobile lab to investigate paranormal activity at two notorious Louisiana landmarks: the Shreveport Municipal Auditorium and the Myrtles Plantation.

The crew heads to Tombstone, Arizona, to see if the long-dead inhabitants of the violent Old West town are exhibiting any signs of life.

To find out if paranormal entities really do feed on fear, the Ghost Lab team investigates alleged hot spots at the Liar's Club in Chicago and the Mortuary in New Orleans.

The team investigates a supposedly haunted tattoo parlor in Chicago and a paranormally active former bordello now used as a bed and breakfast in Fort Worth.

The team investigate the Louisiana Nottoway Plantation and Chicago's Metro Club to test the hypothesis that areas near water hold more paranormal activity.

The team head to Granbury, Texas, to investigate the Opera House, believed by many to be haunted by the spirit of John Wilkes Booth. Next, they move on to the Garfield Furniture store, another location in the same town, said to be linked to Booth.

The team investigate a supposedly haunted restaurant, the Catfish Plantation, in Waxahachie, Texas, said to be haunted by a female spirit who plays havoc in the kitchen and dining room. Next, the team head to the Hotel Lawrence in Dallas, a location with a long history of violence, murder and suicide.

The team heads to Texas and Illinois in search of the elusive "Shadowman." The investigation begins at the GDC building, a Civil War era hotel renovated into an office building. Then they head to the Volo antique mall to test the "Attachment Theory".

The team heads to Texas to investigate the Hotel Galvez which was built atop the wreckage of the deadliest natural disaster in American history. Then they investigate Presidio La Bahia where hundreds of Texan revolutionaries were slaughtered.

The Ghost Lab team heads to the notorious Alcatraz Island - reputedly America's most haunted prison - for a chilling investigation of alleged spirits that are causing the prison's present to be just as terrifying as its past.

The Ghost Lab team embarks on a paranormal treasure hunt to track the ghost of the notorious pirate Blackbeard. Then they venture up the Mississippi to see if a majestic steamboat is still under the watchful eye of a deceased captain.

The team investigates the USS Lexington; a massive WWII aircraft carrier alleged to be haunted. Later, Brad & Barry check into the Ye Kendall Inn where an underground tunnel could be a passageway to the beyond.

The team heads to the Lemp Mansion in St. Louis to investigate the home of a brewing dynasty that has been cursed by murders and suicide. Then they explore McPike Mansion, a rotting condemned estate with alleged apparitions and disembodied voices.