A mother and son travel from Boston with hopes of adopting a dog, but Tia struggles to find a good fit for the family. Lizzy rescues a maggot-covered dog that was found lying on the road and races to the vet, hoping to save her.

A new inmate from starts working at VRC, hoping to fill the big shoes that Country Matt left behind. Lizzy and Joe struggle to catch a stray in a nearby neighborhood. A family comes to Villalobos to adopt a dog, hoping to fill a void in their hearts.

A couple from New Jersey falls in love with a new best friend but the adoption gets put on the line when Dr. Kristen discovers a heart murmur; Tia heads out to the swamps to rescue a dog in need of medical attention and the diagnosis shocks her.

Villalobos' oldest resident, Summer, a pit with severe arthritis, has a chance at a forever home. Earl works to improve a dog's social skills, hoping to make him more adoptable. And Kanani's girlfriend, M2, takes on her first rescue.

A call in the middle of the night sends Tia racing to deal with a family emergency. A homeless man reaches out for assistance when his dog has trouble breathing. A healthy dog tied up outside VRC leads to a shocking story and a difficult decision.

After Tia and Sugar rescue a stray, they are shocked by what they find and race him to the vet. New worker Darius pursues his dream of working in the veterinary field. And an empty nester heads to Villalobos looking for a new companion.

Earl takes the lead in restoring an abandoned Rottweiler back to health. A service dog organization from North Carolina reaches out to Villalobos in search of a new dog for their program. M2 goes on her second rescue, taking in an owner surrender.

Concerned about flooding in Assumption Parish, Tia seeks a solution for how she and the dogs would be able to evacuate quickly; Joe feels a special bond with an injured dog he rescues off the street and takes him under his wing.

A California man hopes to find a new dog to stay by his side as be battles cancer. After Lizzy rescues a sick dog, she rushes to the vet, hoping it's not too late. Tania and Perry prepare to embark on a new chapter in life: parenthood.

With Villalobos' country location overrun with hounds, Tia turns to a trusted parolee and his new wife to help get one of the lovable but troublesome dogs a new home.