It's all about snakes in this episode. Billy has to trap a deadly rattlesnake in a family's backyard and then finds himself wrestling with a 15-foot python that wraps itself around his neck.

Aggressive bees that Billy suspects are Africanized sting him repeatedly while he's trying to remove a hive up high on a column in a New Orleans neighborhood. The homeowner is allergic but one of the tenants dresses up to make sure the bees are removed unharmed so Billy has his work cut out for him.

Billy is called to a homeless shelter in New Orleans with a massive rat infestation that nobody can solve. If Billy doesn't get to the bottom of it they will be forced to close. When his bait keeps disappearing Billy realizes that another disgusting pest has been sabotaging him and doubles his efforts to stamp them out.

A desperate family asks Billy to help them with an aggressive bee colony that has taken over their entire house. Billy takes multiple stings and for the first time ever has to run from the bees to avoid being swarmed.

Billy is called out to Chicago to deal with a nasty rat infestation in a downtown apartment basement. Listen to them squeal when he catches some by hand trying to creep around him in the dark. The squealing continues when Billy helps rescue a fat squirrel stuck in a suburban household pipe the next day.

A feisty gator proves to be a worthy opponent for Billy as he's learning how to hand capture gators. Later, he and Ricky help to rescue a 14-foot albino python that they come across in the middle of the road.

Billy is called to save a family under siege from critters. With a raccoon that's behaving badly around the kids and a giant beehive next to the playhouse, the family backyard has become a nest of horrors--and it's up to Billy to save them.

Billy is in Baton Rouge battling a huge bat colony that has taken over a homeowner's attic. Then he gets an emergency call about a ten-foot reticulated python hanging out in a family's' pool. He jumps in to grab it and finds himself in an unexpected underwater struggle.

Billy and Ricky visit the most terrifying spot in New Orleans, and run into some nasty critters that have been terrorizing the demons and ghouls. It's a race against time as they strive to save the undead from the living!

Billy is called out to battle a giant alligator that's eating everything in a lake--and eyeing the family dog for desert! Later, Billy and Big Bill are called out to handle an emergency raccoon that's trapped at a local business.

Billy tears it up on the racecourse when he sets some traps for some unwanted speed bumps on the track. Big Bill takes a high speed spin but gets a sharp wake up call from Miss Donnie when his heart monitor goes off and Billy is shocked by what he finds in his trap.