Dr. Pol performs emergency surgery on a dog that swallowed a rope toy. Dr. Nicole examines a tiny kitten with a big eye problem, and Dr. Lisa helps a horse suffering from heaves. A fungal infection glows on a Pomeranian while a lump grows on a Pitbull. The Pols celebrate their 55th wedding anniversary with cake decorated by grandkids, Silas and Abigail.

The country fair is in full swing. Preparations for the event have taken a lot of time, as the animals have to be presented in top form. And of course there are always minor and major emergencies during the fair, so the vets have to be on alert practically around the clock. Among other things, Dr. Pol treats a goat with a damaged ear, while Dr. Lisa examines a limping cow in detail. Meanwhile, at the clinic, Dr. Nicole is working tirelessly to save a dog's life.

Dr. Pol treats bovines and a rabbit before a trip to the Netherlands for his 80th birthday. With the Doc away, a vocal pig needs hernia surgery, a blocked cat requires relief, and a puppy feels ill from eating something inedible.

Dr. Pol helps a choking horse. Vets Lisa and Brenda treat cats Mushi and a fussy feline. Doc meets steer Dr. Strange. Charles worries for dog Athena and seeks dad's guidance.

A small-town vet clinic faces a busy summer. Vets struggle healing an injured cat, wounded farm dog, and wobbly mini horse. Ferret and chicken pairs also need care. The vets' new puppy stirs happy chaos.

Pregnant pup, goose, bunny occupy Pol Vet staff. Dr. Pol builds calf's cast. Blocked reindeer gets sudden relief. Vets treat injured pets after staffer intake. Lisa chases loose goats, altering plans.

It’s the most wonderful time of the year! As PVS decks the halls, a reindeer’s hurt hoof threatens his Christmas Eve take-off. Dr. Pol treats an abandoned puppy discovered on a cold silent night. Dr. Nicole rushes to a cow that isn’t acting right while Dr. Lisa assists a young cat struggling to breathe.

It’s starting to look like winter in Michigan. The cold weather doesn’t stop Dr. Brenda from responding to an afterhours farm call to treat a down cow. Dr. Pol helps a German Shepherd that is in pain after eating cooked bones. Dr. Lisa uses a portable ultrasound to pregnancy check a highland cow, and Dr. Nicole staples a wound hidden under an Aussiedoodle’s thick fur. During breaks in the cases, Dr. Lisa leaves the clinic to go cross country skiing, and the Pol family gathers to go sledding.

Everything feels connected as the vets see patterns emerge in their cases. Treating back-to-back Australian Shepherds, waves of animals suffering respiratory ailments, and a rush of lumps and bumps keeps the team hustling. Although the symptoms, breeds, and names can feel alike, no two cases are really the same.

Surprises come in all scrapes and sizes. A cockatiel has a tweaked beak and Dr. Lisa ponders a barn cat’s bladder leak. When a Chihuahua arrives after hours with an eye emergency, Doc remains focused. A serious blemish surfaces on a show dog and a hoarse horse struggles to breathe. Everyone comes together to make Diane’s birthday extra special.