Actors Kristen Bell and Dax Shepard face off in a series of Battle of the Sexes games designed to illustrate the differences between female and male brains.

Actor Ted Danson learns how human brains distinguish fact from fiction in a series of games.

NFL football player Drew Brees puts his brain to the test with a series of mental challenges exploring how humans have hacked their brains; Keegan and Drew play a game called Draft Day, which shows how the brain must react quickly and be flexible.

Actors Anthony Anderson and Marsai Martin ("Black-ish) face off in a series of games with host Keegan-Michael Key.

Actor-musician Jack Black and his Tenacious D bandmate Kyle Gass learn how music affects the brain.

Keegan-Michael Key welcomes billionaire CEO and reality star Mark Cuban ("Shark Tank") to the show.

Actress Rebel Wilson joins Keegan-Michael Key to explore the power of the subconscious when it comes to falling in love.