Season 4 (2017)
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1. Lance Armstrong
Neil deGrasse Tyson features his interview with Lance Armstrong and discusses the science of cycling with Scott Adsit, Max Glaskin, and Arthur Caplan.
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October 1, 2017
2. Kareem Abdul-Jabbar
Neil deGrasse Tyson features his interview with Kareem Abdul-Jabbar and discusses the science of basketball with Chuck Nice and Charles Liu.
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October 8, 2017
3. Jane Goodall
Neil deGrasse Tyson features his interview with Jane Goodall and discusses chimpanzee behavior with Chuck Nice and Jill Pruetz.
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October 15, 2017
4. Katie Couric
Neil deGrasse Tyson features his interview with Katie Couric and discusses the intersection of science and journalism with Eugene Mirman and Jeff Jarvis.
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October 22, 2017
5. Kevin Smith
Neil deGrasse Tyson features his interview with Kevin Smith and discusses science fiction and the science of superheroes with Chuck Nice and Charles Liu.
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October 29, 2017
6. SciFi Meets National Defense
Host Neil deGrasse Tyson features his interview with former head of DARPA Arati Prabhakar.
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November 5, 2017
7. Katy Perry
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November 12, 2017
8. Sylvia Earle, Fabien Cousteau & Adrian Grenier
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November 19, 2017
9. James Cameron
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November 26, 2017
10. Celestial Navigation
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December 3, 2017
11. Salman Rushdie
Neil deGrasse Tyson interviews Salman Rushdie and explores the science of storytelling with comedian Eugene Mirman and literary scholar Jonathan Gottschall.
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December 10, 2017
12. Interstellar Space Travel
Neil deGrasse Tyson features his interview with Mae Jemison and discusses the challenges of interstellar travel with Godfrey and Lawrence Krauss.
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December 17, 2017
13. Alan Alda
Neil deGrasse Tyson features his interview with Alan Alda and discusses science communication with Matt Kirshen and Heather Berlin.
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January 7, 2018
14. Stephen Colbert
Neil deGrasse Tyson features his interview with Stephen Colbert and discusses the intersection of science and comedy with Adam Conover and Sophia McClennen.
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January 14, 2018
15. True Story of Hidden Figures
Host Neil deGrasse Tyson interviews author Margot Lee Shetterly ("Hidden Figures: The American Dream and the Untold Story of the Black Women Mathematicians Who Helped Win the Space Race") and actress Janelle Monáe, who starred in the movie.
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January 21, 2018
16. Sam Harris and the Science of Belief
Neil deGrasse Tyson interviews neuroscientist Sam Harris, and discusses everything from free will to religion with Godfrey and Andrew Newberg.
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January 28, 2018
17. Frank Oz and the Science of Puppeteering
Neil deGrasse Tyson features his interview with puppeteer Frank Oz, then discusses puppets in pop culture and the people "behind the curtain" with Adam Conover and Charles Liu.
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February 4, 2018
18. Kelly Slater and the Science of Surfing
Neil deGrasse Tyson features his interview with surfer Kelly Slater, then discusses the science of surfing with Chuck Nice and William Finnegan.
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February 18, 2018
19. Astronaut Scott Kelly
Host Neil deGrasse Tyson features his interview with astronaut Scott Kelly.
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February 25, 2018
20. Stephen Hawking
Host Neil deGrasse Tyson interviews world-renowned physicist Stephen Hawking.
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March 4, 2018