Ozzy is planning his final world tour, but is hounded to do press, promos and photos which he hates. He tries to persuade Jack to hit the road but Jack has one problem–his new baby is due to be born and he can't leave LA. Ozzy and Jack conspire to convince his sister, Kelly to take the wheel if Jack has to stay behind.

With Jack stuck in L.A. waiting for his baby to be born, Kelly and Ozzy head for Arizona. They tour the impressive Biosphere, followed by a night of beauty masks.

Ozzy and Kelly are awoken by a call from Jack that his new baby is going to be born; after returning to Los Angeles, the Osbournes manage to welcome a new family member, squeeze in a quick camping trip to Joshua Tree, and even have dental surgery.

Jack travels once again with Ozzy and his sister, Kelly, now that his baby has been born. They explore the state of New Mexico, sampling chili milkshakes, chainsaw sculpting, and learning to make pistachios. Kelly hates dealing with all the guy humor that Ozzy and Jack deal out, but figures out a way to make a profit from it.

In Missouri, Kelly takes the guys to eat some fresh ice cream, while Jack arranges a trip to an "explosion school"; Jack and Kelly plan some touching surprises for Ozzy; old nemesis "Robert the Doll" returns and threatens to derail the trip.

For the first time in the show’s history, Kelly heads the trip. They go to Nashville, Tennessee. Jack and Ozzy are backseat to some very “Kelly” activities, including a drag queen brunch; visiting Manuel, Nashville’s iconic fashion designer; and restyling Ozzy’s Madame Tussauds’ wax figure. Not entirely excluding her father and brother’s interest, they visit a chocolate and record pressing factory. Kelly plans a musical surprise for Ozzy and makes a trip to the largest ashram in the country.

With Pearl in tow, Ozzy and Jack head to Alabama, where Jack’s childhood dream will be fulfilled at Huntsville’s Space Camp. However, before they can launch into space, Ozzy has a surprise up his sleeve for Jack.

In Florida, Jack and Kelly meet with a chocolate sculptor who makes a bust of Ozzy and visit the famed Fountain of Youth to retrieve some magical water; a psychic attempts to remove any bad luck before Ozzy takes the stage at a music festival.