Wayne Wolfe Jr. discovers his grandfather was the serial killer Edward Wayne Edwards and teams up with retired detective John Cameron. They examine Edwards as a suspect in various murder cases including The Zodiac, JonBenet Ramsey and many more.

Wayne and John head to San Francisco where they examine Edwards involvement in one of the most chilling unsolved cases in American history – the Zodiac murders. Wayne visits his relatives to find out more about his grandfather.

John Cameron has a theory that Edwards was capable of killing children, including the child beauty queen JonBenet Ramsey and the Atlanta Child killer.

John Cameron examines the gulf between Ed Edwards's public persona and his secret life as a killer, which may have included the murder of union leader Jimmy Hoffa.

The guys examine the origins of Edwards becoming a serial killer. Ed's mother died when he was a toddler and John has a theory that he relived the experience of her death by killing brunettes like Laci Peterson and the Black Dahlia.

John has come under fire for his theories and Wayne has reached a breaking point trying to understand his own past. They investigate Edwards connection to one of the most notorious unsolved murders in Oregon history.