Case File #898750 As the third season begins, physicist Peter Axon is the only remaining member of the Office of Scientific Investigation and Research team. Dr. Anton Hendricks is apparently dead, having disappeared into a mysterious apportation device known as the Arch, case manager Matt Praeger has tendered his resignation after differences with the O.S.I.R.'s Director of Operations Frank Elsinger and senior data analyst Lindsay Donner has left the team after running afoul of Praeger and revealing confidential information. Axon and Curtis Rollins, the case manager assigned to the Arch case, take their investigation to a remote area of northern Quebec after an RCMP officer finds a woman wandering alone in the sub-tundra. It turns out the woman had vanished into the Arch and then re-appeared 2,000 miles away. Lindsay Donner and Matt Praeger rejoin the team to recover Hendricks from the Arch.

Case File #751718 Following a memorial service for Dr. Anton Hendricks the Office of Scientific Investigation and Research team members receive an anonymous phone call informing them that Hendricks is at a nearby hospital unconscious and on a ventilator.

Case File #898777 When a forest area turns into a bone-dry wasteland virtually overnight, a government agriculture official turns to the Office of Scientific Investigation and Research for help.

Case File #145345 The Office of Scientific Investigation and Research is called into action when the mutilated corpse of a police detective who gunned down an escaped convict is found in a dumpster.

Case File #569-977 The Office of Scientific Investigation and Research case manager Matt Praeger is institutionalized after a case goes tragically wrong. Working undercover as an arms dealer in order to gain access to a teenager with ESP Praeger gets caught in the middle of a double cross and apparently fires the bullet that kills the youth.

Case File #659-311 The Office of Scientific Investigation and Research case manager Matt Praeger, security co-ordinator Ray Donahue, chief science analyst Peter Axon and senior data analyst Lindsay Donner visit the scene of a grisly, pre-Halloween murder of two college students who died after having their faces torn off.

Case File #600-001 The Office of Scientific Investigation and Research investigates after the body of an elderly woman is found in the basement of a soon-to-be demolished apartment building.

Case File #965-789 Dr. Anton Hendricks' wife has recently returned from a mysterious apportation device called the Arch, into which she vanished 12 years ago. Hendricks has become increasingly suspicious that she is not the Catherine he knew.

Case File #828-456 The Office of Scientific Investigation and Research investigates the unusual death of a large South American rodent called a capybara at the Windsor Animal Hospice.

Case File #790-002 Matt Praeger's daughter, Dana, is sleeping over at the country home of her friend, Vanessa, when the girls hear a strange noise coming from the bedroom of Vanessa's adopted brother. The Office of Scientific Investigation and Research team arrives at the house to conduct an ""unofficial"" investigation.

Case File #340-872 Archaeologist and former lover of Lindsay Donner finds a 13th century burial shroud inside an ancient Druid coffin. At his request, Donner and the Office of Scientific Investigation and Research team join him in London to verify the authenticity of the ""winding cloth"" and identify the man buried in it.

Case File #500-208 A senior data analyst of the Office of Scientific Investigation and Research dies of an apparent heart attack at a Cuban-style neighborhood party. The rabbi who's conducting the funeral suddenly hears scratching sounds coming from coffin, opens the lid and finds out the man is alive.

Case File #226-051 The Office of Scientific Investigation and Research senior data analyst Lindsay Donner and pathologist Claire Davison are called to the Newgate Correctional Facility after an inmate dies mysteriously while in solitary confinement.

Case File #443-987 Alone on Valentine's Day, Lindsay Donner visits a neighborhood after-hours club, where she catches the attention of the bartender. Despite the attraction Donner leaves and is called back to the vicinity the following morning when a body is found in the alley.

Case File #392-101 Tessler Industries, a video-game giant, is testing one of its new virtual-reality war games at the Office of Scientific Investigation and Research Central Lab. When a woman is knocked to the floor with a very real head wound, Elsinger calls for the O.S.I.R. team to investigate.

Case File #222-989 The Office of Scientific Investigation and Research investigates after a UFO is sighted in the woods near the private community of Poplar Glen.

Case File #333-016 The Office of Scientific Investigation and Research team investigates after an auto shop teacher at Royalton Custodial School is crushed against a wall by a car. The ""accident"" could be the work of a student with telekinetic ability.

Case File #009-873 Two computer programmers trying to develop a solution to the Y2K problem enter a sealed lab and begin work. Later, they go into convulsions and, with blood pouring from their eyes and ears, fall to the ground dead. The Office of Scientific Investigation and Research team arrives at the lab to investigate.

Case File #899-997 The Office of Scientific Investigation and Research is transporting a young woman who's had an alien encounter, when their van is engulfed in a bright light from a UFO, temporarily blinding the investigator, and the woman disappears.

Case File #098-509 Peter Axon and Frank Elsinger run tests on an electromagnetic field (EMF) laser cannon in the lab at Tessler Industries to destroy a missile guidance system. After the experiment fails when the laser device overheats, a janitor resets the cannon and destroys the missile guidance system.

Case File #298-321 Psychic healer has just successfully restored the sight of a blind woman when he is interrupted by the Office of Scientific Investigation and Research agents and taken to the central lab to test the man's healing powers.

Case File #298-321 Peter Axon is working on a secret project for the Office of Scientific Investigation and Research head Frank Elsinger that seems to have special and very personal significance for Elsinger, who assigns case manager Curtis Rollins to provide security for Axon as he finishes the project, which involves mapping out an anonymous individual's genetic code.